Hepatocyte Growth Factor/Scatter Factor Can Induce Angiogenesis Independently of Vascular Endothelial Growth Factor

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Hepatocyte growth factor/scatter factor can induce angiogenesis independently of vascular endothelial growth factor.

OBJECTIVE Hepatocyte growth factor/scatter factor (HGF/SF) promotes vascular endothelial growth factor (VEGF) expression and induces angiogenesis in multiple pathological conditions. The present study was designed to delineate the HGF/SF and VEGF signaling cascades during angiogenesis by using PTK787, a selective VEGF receptor antagonist. METHODS AND RESULTS PTK787 produced a concentration-de...

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ژورنال

عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology

سال: 2003

ISSN: 1079-5642,1524-4636

DOI: 10.1161/01.atv.0000048701.86621.d0